Morgan Greenhalgh

Correlation and you will regression analysis

We performed correlation analysis in each treatment modality group comparing the ISVs with the biodosimetric values measured at different time points. After Benjamini–Hochberg correction of multiple testing we found that 9 months after LDR therapy the chromosome aberration values (dicentrics + rings, chromatid deletions, total aberration and aberrant cell values) correlated positively and significantly with the largest ISVs, namely V_1%, V_1Gy. The correlations were weak, between 0.37 and 0.45 (Table 2). In HDR therapy, 3 months after radiotherapy dicentric plus rings correlated positively and weakly with most ISVs (Table 3). Aberrant cell number correlated with V_150% at this time point as well (Spearman correlation coefficient 0.41). We found no correlations in any other time points of the follow-up. In the EBRT treatment group, the ISVs showed significant positive correlations with various chromosome aberrations directly after the radiotherapy, at the 3rd, 6th and at the 12th month. The aberrations which correlated with the most ISVs are shown in Table 4. Furthermore, the Spearman correlation coefficient for V_10Gy are 0.52 and 0.51 for dicentrics + rings and aberrant cells at 3 months, respectively. The frequency of chromatid breaks and aberrant cells correlated with V_10Gy (Spearman correlation coefficient 0.50 and 0.56) and aberrant cell number with V_10% (0.49) at 6 months. Total aberrations (0.48) and aberrant cell number (0.43) showed correlation with V_10Gy at 12 months.

Univariate regression analysis was performed to explain the variance of chromosome aberrations by variables of ISVs. Multiple regression cannot be used, because of the high collinearity of the variables. We sumini–Hochberg correction in Tables 4 and 5. In case of LDR therapy, we found, that none of the ISVs were significant predictors of chromosome aberrations (p > 0.2 R 2 < 6.4% at the ninth month after therapy). However, at the third month after HDR the predictive value (R 2 ) varied between 26.0 and 31.7, the best predictor being V_{100% (p = 0.004, R 2 = 31.7%) (Table 5). More >}

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Machine-Learning Malware Safety

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